乳腺癌术前应用米托蒽醌的研究

Pre-operative mitoxantrone treatment for breast cancer

作者于1986年12月至1988年6月对15例准备手术的乳腺癌患者应用米托蒽醌观察其治疗效果及疗后组织形态学改变。结果表明,用药7天后乳腺肿块均有不同程度缩小。手术切除标本镜下可见瘤细胞核染色体断裂,核固缩、线粒体破坏,出现空泡。间质中亦可见少数毛细血管及结缔组织增生性反应。在瘤细胞受到抑制的背景下选择手术时机,将对降低局部复发及远处转移带来好处。

15 patients with breast cancer were treated pre-operatively by mitoxantrone from 1986 to 1988. Clinical therapeutic effect and histologic morphalogical changes of the cancer were observed and studied. The results showed that the tumor mass reduced after treatment of 7 days. Cancer cell karyopyknosis, karyorrhexis, mitochondrian breaking and vacuolization in the resection samples can be seen. Reactive regeneration of capillaries and connective tissue were also found with microscope. The chance of recurrence and metastasis will be reduced when the operation is performed after the tumor cells are inhibited by mitoxantrone.