胎肝无细胞悬液的实验研究及临床应用

CLINICAL APPLJCATION AND LABORATORY INVESTIGATION ON THE NONCELLULAR SUSPENSION OF FETAL LIVER

为探讨胎肝细胞作用机理,把胎肝细胞裂介,分离成二种不同悬液,结合电镜,超微弱自发发光测定,对22例白血病,淋巴瘤,再生障碍性贫血病人,二种悬液用自身对比,随机使用。观察到胎肝细胞上清液,存在造血细胞抑制物。胎肝细胞裂介液,存在造血细胞刺激物,后者在刺激血象回升疗效,与全胎肝悬液输注比较,未显示优于全胎肝细胞输注。本工作说明胎儿肝脏中存在造血抑制与刺激两类物质。

To clarify the mechanism of fetal liver transfusion in stimulation of hematopoiesis in vioo, fetal liver cell suspension was divided two parts, fetal liver supernatant and fetal liver lysate, and transfused separately into a group of leukemia patie -nts after a course ofchemo-therapy and the other group of aplaslic anemia. From the ch anges of peripheral blood cell counts it is concluded that the effectiveness of fetal liver transfusion is not due to the integrityof the cells infused, but mainly due to the presence of hemopoietic stimulators in fetal liver cells.