经皮冠状动脉内球囊成形术后血管活性物质的变化

Vasoactive Substance Variation after PercutanueossTransluminal Coronary Angioplasty

本文分析了２５例冠心病患者在ＰＴＣＡ前，ＰＴＣＡ后１ｄ，３ｄ和７ｄ的血浆ＥＴ、ＣＧＲＰ、ＳＰ和ＮＰＹ变化，发现ＥＴ由ＰＴＣＡ前的２１．４１±４．０１ｎｍｏｌ／Ｌ增加到ＰＴＣＡ后的４７．７６±１４３５ｎｍｏｌ／Ｌ，（Ｐ＜００１）在ＰＴＣＡ后３ｄ和７ｄ逐渐回降；ＣＧＲＰ由ＰＴＣＡ前的２．９５±１．２１ｎｍｏｌ／Ｌ增加到ＰＴＣＡ后的１７．９６±３．３４ｎｍｏｌ／Ｌ（Ｐ＜００１），在ＰＴＣＡ后３ｄ和７ｄ逐渐回降至术前水平；ＳＰ在ＰＴＣＡ后３ｄ和７ｄ明显降低；ＮＰＹ由ＰＴＣＡ前的１５２±０２７ｎｇ／Ｌ增加到ＰＴＣＡ后的３．４７±１２ｎｇ／Ｌ（Ｐ＜００１），在ＰＴＣＡ后３ｄ已回降至术前水平。认为ＰＴＣＡ术可以引起体内血管活性物质的变化，这些变化可能与ＰＴＣＡ并发证有关。

We analyzed 25 cases plasma ET, CGRP, SP and NPY changes in pre-PTCA, post-PTCA1 d, 3 d and 7 d. It was found that ET increased from 21. 41±4. 01 nmol/L in pre--PTCA to 47. 76±14. 35 nmol/L, (P<0. 01)in post-PTCA 1 d and then gradually decreased to nearly pre-PTCAlever in post-PTCA 3d and 7 d; CGRP increased from 2. 95 ± 1. 21 Pmol/ml in pre-PTCA to17. 96 ± 3. 34 Pmol/ml (P<0. 01)in post--PTCA 1 d and then gradually recovered to pre-PTCAlevel in 3 d and 7 d; SP significantly decreased in post-PTCA 3 d and 7 d, compared withpre-PTCA ; NPY increased from 1. 521±0. 27 ng/L in pre--PTCA to 3. 47± 1. 2 ng/L(P<0. 01) inpost--PTCA 1 d and then recovered to pre--PTCA level in post--PTCA 3 d. Conclusion: PTCA mayinduce vasoactive substance changes in body, and these changes may induce complications ofPTCA.