2型糖尿病患者骨密度的测定

Measurement of bone mineral density in patients with type 2 diabetes mellitus

目的 观察 2型糖尿病对骨密度 (BMD)的影响。方法 应用双能 X线吸收仪 (DEXA)测定 6 3例 2型糖尿病患者腰椎 (L2～ 4 )和髋关节部位的骨密度 ,并与正常对照组比较。结果 绝经后女性 2型糖尿病患者腰椎 (L2～ 4 )骨密度与对照组比较下降但无统计学意义 ,股骨 (total)骨密度较对照组下降 (P<0 .0 5 ) ,股骨颈 (neck)骨密度较对照组明显下降 (P<0 .0 1) ;5 0岁以上男性 2型糖尿病患者腰椎 (L2～ 4 )骨密度与对照照比较升高 ,而股骨及股骨颈骨密度较对照组降低但均无统计学意义。结论 2型糖尿病患者各部位 BMD依性别不同而不同 ,绝经后女性 2型糖尿病患者易发生骨密度下降 ,特别是股骨颈部位骨密度下降更明显 ,应引起重视以防病理性骨折 ;5 0岁以上男性 2型糖尿病患者骨密度较正常人无明显改变。

Objective To investigate the changes in bone mineral density(BMD)in patients with type 2 diabetes mellitus.Methods BMD of lumbar vertebrae 2～4 and femur in 63 cases of patients with type 2 diabetes mellitus were measured with dual energy X ray absorptiometry(DEXA)and were compared with those in the age,sex and BMI matched normal control group.Results No significant differences were found in BMD of lumbar vertebrae 2～4 in menopause female with type 2 diabetes mellitus( P >0.05),but BMD of total of femur was lower than that of the control( P <0.05),BMD of femur neck was significantly lower than that of the control( P <0.01).No significant differences were found in BMD of lumbar vertebrae 2～4 and femur in males of 50 years old above with type 2 diabetes mellitus( P >0.05).Conclusion BMD of type 2 diabetes mellitus is different in different sexes,BMD of menopause females with type 2 diabetes mellitus descended easily,especially in areas of neck femur.Attention should be paid to the prevention of pathologic bone fracture;BMD of males of 50 years old above with type 2 diabetes mellitus showed no the obvious changes compared with that of the control.