摘要
目的 探讨卵巢上皮性癌血清CA12 5的动态变化 ,在预测术前病人临床分期、估计预后、早期发现复发中的价值 ,以指导临床治疗。方法 采用放射免疫方法对 5 2例卵巢上皮性癌患者血清CA12 5进行连续监测。术前测定一次 ,术后每月测定一次 ,连续两年以上。结果 5 2例卵巢上皮性癌患者术前有 4 7例血清CA12 5>35ku/L ,诊断敏感性为 91%。血清CA12 5水平与临床期别有关 ,临床期别愈晚 ,阳性率愈高 ,血清CA12 5值也愈高 ;各期术后 1个月血清CA12 5值均较术前明显下降 ,P <0 0 1;有 2 5人两年内复发 ,其中 2 3人复发前平均 3 7个月血清CA12 5升高。术后 4个月未控的 5人中 ,4人术后血清CA12 5一直无明显下降 ,1人术后 2个月降至正常 ,第 3个月又上升。结论 血清CA12 5水平与临床期别有关 ,监测血清CA12 5对卵巢上皮性癌的诊断、指导治疗、预测复发。
Objective To study the dynamic change of serum CA 125 in epithelial ovarian cancer.Methods Utilizing serum from 52 patients with epithelial ovarian cancer,CA 125 was measured by radioimmunoassey(RIA) preoperative and every month of postoperative continuous measuring more than two years.Results 47 patients with epithelial ovarian cancer were CA 125 >35 ku/L.Diagnosis sensitivity was 91%.There were correlation between the level of serum CA 125 and clinical stages.The serum CA 125 was higher when the patients clinical stage was later.Every clinical stage one month after operation the serum CA 125 were more fall than preoperative( P <0 01) 25 patients were recurrence in 2 years.There are 23 cases serum CA 125 rise in 3.7 months.Conclusions There were correlation between the level of serum CA 125 and clinical stages.it is important of measuring the serum CA 125 for diagnosis,treatment,prediction recurrence and evaluate the therapeutic effectiveness of epithelial ovarian cancer.
出处
《河南职工医学院学报》
2002年第3期222-224,共3页
Journal of Henan Medical College For Staff and Workers
