血管内皮生长因子在肾癌中的表达及其作用

THE EXPRESSION AND CLINICAL SIGNIFICANCE OF VASCULAR ENDOTHELIAL GROWTH FACTOR IN RENAL CELL CARCIONMA

目的 探讨血管内皮生长因子 (VEGF)的表达与肾癌侵袭、转移等生物学行为的关系。方法 采用免疫组织化学技术对 4 2例肾癌和 9例正常肾组织中VEGF及微血管密度 (MVD)进行检测。结果 4 2例肾癌组织中VEGF阳性表达 2 7例 (6 4.3% ) ,MVD均值为 (6 4.38± 2 5 .17) ,显著高于正常肾组织 (P <0 .0 1)。肾癌组织中VEGF表达和MVD与其组织类型、分级、淋巴转移及 5年生存期都明显相关 (P <0 .0 1)。结论 肾癌组织中VEGF。

Objective To study the relationship between the expression of vascular endothelial growth factor(VEGF),the microvessel density(MVD) and invasion,metastasis and orther biological behaviors of renal cell carcinoma.Methods The expression of VEGF and MVD in 42 cases of renal carcinoma and 9 cases of normal renal tissues were detected by immunohistochemistry.Results The level of VEGF and MVD in renal carcinoma was higher than that in the normal renal tissues(P<0.01).VEGF expression and MVD were significantly correlated to histologic type,tumor grade,lymph node metastasis and 5 year survival duration.Conclusion VEGF expression and MVD are highly related to the biological behaviors of renal cell carcinoma,and they are therefore probably the prognostic predictors of renal cell carcinoma.