摘要
为了探讨对氯基水杨酸钠(PAS-Na)治疗锰中毒的作用机理,给小鼠每天ip Mncl_2(0、10、20、40mg/kg)染毒,4周后给予PAS-Na(120mg/kg),连续2周。结果表明;PAS～Na能增加脾NKC活性,增强T细胞功能。PAS-Na可能通过驱出体内的锰或与锰拮抗.恢复部分细胞免疫功能。
In an attempt to elucidate the mechanism for the treatment of Mn pois-oning by PAS-Na,mice were injected (ip) daily with 0,10,20,40mg/kg of Mncl_2 for 4wks,after which 120mg/kg of PAS-Na was givenfor 2 wks.Results showed that PAS-Na can increase splenic NKC activityand enhance T lymphocyte functions,indicating that PAS-Na may partiallyrestore cellular immunological function by either eliminating or antegonizingmanganese in the body.
出处
《中华劳动卫生职业病杂志》
CAS
CSCD
1991年第4期213-215,共3页
Chinese Journal of Industrial Hygiene and Occupational Diseases
关键词
氨基水扬酸钠
锰
小鼠
免疫功能
PAS-Na
Manganese
Immunological
Function
Natural
Killer
Cell
