镁锌锶离子掺杂HA的组成结构和抗菌性能

Phase Composition, Structure and Antibacterial Performance of Hydroxyapatite Doped with Mg, Zn or Sr Ions

系统研究了Mg、Zn和Sr掺杂改性HA的取代规律及其对掺杂HA相组成和晶体结构的影响。制备具有单一组成的掺杂HA,Mg、Zn或Sr离子的掺杂量宜控制在40%(at%)以下。与Zn或Sr离子掺杂HA相比,Mg离子掺杂对HA的结晶性能具有明显的抑制作用。细胞生物学性能研究表明,选择适合的掺杂离子,有望获得具有刺激骨生长和抗菌特性的新型生物材料,可为进一步研究掺杂改性HA的生物学性能、开发生物活性抗菌骨诱导陶瓷材料提供一定的研究基础。

The substitution regularity of Mg, Zn or Sr doped hydroxyapatite(HA) and the effects of doping ions on the phase composition and crystal structure of HA were studied. To synthesize metal ions doped HA with single phase composition, the doping content of Mg, Zn or Sr should be controlled below 40at%. Compared with Zn or Sr ions doped HA, the crystallinity ability of Mg doped HA is obviously inhibited. The research result of cell biology reveals that selecting appropriate doping ions would be expected to favaor the preparation of novel biomaterials with bone stimulated-growth and antibacterial ability, which would provide a fundamental basis for further research on their biological properties and development of novel biomaterials with good biological activity, antibacterial and osteoinductive bioceramic materials.