医用近β型钛合金TLM的水热预钙化与生物活性

Hydrothermal Pre-calcification and Bioactivity of Medical Near β-Type Titanium Alloy TLM

医用近β型钛合金TLM(Ti-25Nb-3Zr-2Sn-3Mo)具有优良的力学和生物学性能,采用CaCl2溶液对TLM合金进行水热处理,以达到预钙化的目的。TLM合金经过纯水水热处理后,表面形成了锐钛矿二氧化钛(含五氧化二铌)的纳米颗粒薄膜;采用10 mmol/L CaCl2溶液进行水热处理时,颗粒尺寸减小,检测到钙元素;当CaCl2溶液的浓度升高到100 mmol/L时,结晶颗粒消失,形成了钙的化合物薄膜。水热处理试样在模拟体液中浸泡3 d后,表面均有磷酸钙沉积物生成,前2种试样检测到磷灰石的弱衍射峰。CaCl2溶液水热处理预钙化方法可用于多孔钛及多孔钛合金的生物活性表面改性,该方法具有改性层厚度薄,消耗溶质和溶剂少,反应物扩散快,处理温度较低,工艺简便等优点。

Medical near ?-type titanium alloy of TLM(Ti-25Nb-3Zr-2Sn-3Mo) has good mechanical and biological properties. In this work, TLM alloy was hydrothermally treated with CaCl2 solutions for the purpose of pre-calcification. After hydrothermal treatment with pure water, nanoparticles of anatase TiO2(containing Nb2O5) are formed on the alloy surface. When using 10 mM CaCl2 solution, the size of nanoparticles is reduced and the Ca element is detected for the treated alloy surface. When CaCl2 concentration is increased to 100 mmol/L, the crystalline particles disappear, forming calcium compound thin film. After the hydrothermally treated samples are immersed in the simulated body fluid for 3 d, calcium phosphate deposits are formed at the surface, with weak apatite diffraction peaks detected for the former two samples. The present hydrothermal pre-calcification method using CaCl2 solution can be used for bioactive surface modification of porous titanium or porous titanium alloys, with the advantages of thin modification layer, small consumption of solute and solvent, quick diffusion of reactants, low treatment temperature, ease in processing, etc.