纳米银/氧化细菌纤维素复合抑菌材料的制备和表征

Preparation and Characterization of Nano-silver/Oxidized Bacterial Cellulose Composites

本实验采用高碘酸钠将细菌纤维素C6位的羟基氧化成醛基,同时利用醛基化合物与银氨络合物Ag(NH3)2+的反应,制备了纳米银/氧化细菌纤维素复合抑菌材料。分析了纳米颗粒的形成机制,考察了复合材料的银含量、表面形貌、纳米银粒径和结晶结构等;同时研究了复合材料对金黄色葡萄球菌的抑菌效果和对胎鼠表皮细胞增殖的影响。结果表明,AgNPs-DBC复合材料能抑制细菌的生长,同时不影响表皮细胞的正常增殖和分化,是一种潜在的创伤修复材料。

The hydroxyl group of bacterial cellulose at the C-6 position was oxidized selectively into a aldehyde with periodate sodium. Nano-silver/oxidized bacterial cellulose composites for antimicrobial were prepared by aldehyde compound reaction with silver-ammino complex. The formation mechanism of nanoparticles was analyzed. Silver content, surface morphology, size of silver particles and crystal structure of the composites were studied. The bacteriostatic effect of the composites on staphylococcus aureus and the effect on proliferation of epidermal cell were also studied. The result shows that, AgNPs-DBC composites exhibit significant antibacterial activities, and allow attachment and growth of epidermal cells with no cytotoxicity emerged, so the composites may be potential materials for wound repair.