摘要
首先通过共价键合法制备了羧甲基壳聚糖修饰(CMCS)的Fe3O4-CMCH复合纳米颗粒,然后与谷胱甘肽修饰的Cd Te@Zn S QDs通过酰胺缩合反应连接,并在此复合纳米颗粒表面再修饰一层CMCS,最终制备出以CMCS为基质的磁性荧光复合纳米颗粒。利用XRD、TEM、SEM、FT-IR、UV-vis、VSM和荧光光谱等方法对产物性能进行了表征与分析。结果表明:磁性荧光复合微球具有良好的单分散性,平均粒径为170±5 nm;且具有良好的磁性能和发光性能,饱和磁化强度为37.25 Am2/kg;当加入CMCS的浓度为6×10-10 mol/L时,复合纳米颗粒的荧光强度最强;在模拟人体的生理环境下检测,复合纳米颗粒显示出良好的缓释性能。
The carboxymethyl chitosan modified Fe_3O_4 nanocomplexes was prepared through a covalent bonding method, and then glutathione capped Cd Te@Zn S QDs were deposited on the surface of CMpoly-MNPs complexes via the amide condensation reaction; meanwhile, the magnetic-fluorescent nanobeads were decorated with another CMCS layer; finally the multifunctional nanobeads based on quantum dots and magnetic nanoparticles were synthesized and encapsulated into a CMCS polymeric matrix. The resulting magnetic fluorescent hybrid nanobeads were characterized by XRD, TEM, SEM, FT-IR, UV-vis, VSM and fluorescence luminescence spectrum. The results show that the synthesized hybrids are spherical in shape with an average particle size of 170±5 nm, good monodispersity, magnetic responsivity and luminescence properties. The saturated magnetization is 37.25 emu/g. When the concentration of CMCS is 6×10-10 mol/L, the composite nanobeads have the best fluorescence intensity. Under the simulated human physiological condition, composite nanoparticles show a good sustained release performance.
出处
《稀有金属材料与工程》
SCIE
EI
CAS
CSCD
北大核心
2015年第S1期408-412,共5页
Rare Metal Materials and Engineering
基金
济南市科技局资助(201303060)
