2型糖尿病合并脂肪肝与胰岛素抵抗的关系

ASSOCIATION OF FATTY LIVER DISEASE WITH INSULIN RESISTANCE IN TYPE 2 DIABETES MELLITUS

目的:探讨2型糖尿病(DM)患者中脂肪肝与胰岛素抵抗的关系。方法:对22例糖尿病(2型DM)合并脂肪肝患者计算体重指数,用放射免疫法测定胰岛素水平,用B超诊断脂肪肝,胰岛素抵抗指数用HOMA平衡模法计算。同时在年龄和性别相匹配的情况下设置20例无脂肪肝的2型DM患者作为对照组。结果:脂肪肝组和对照组比较,具有明显高胰岛素血症(P<0.001),高甘油三酯(P<0.05),胰岛素抵抗(P<0.001),其结果同脂肪肝有联系。结论:2型(DM)脂肪肝患者胰岛素抵抗增强。

Objective: To terify the relationship between fatty liver disease and insulin resistance in 22 diabetic Subjects with fatty liver. Method: We calculated body Mass index, ins - ulin levels were measured by radio - immunoassay and fatty Liver were diagnosed by ultrasound Scan. Index of insulin resistance was determined using the homeostasis model assessment method. They were Compared with 20 diabetic Subjects without fatty liver disease who were matched for year and sex. Results: Compared to controlgroup, Patients with fatty liver disease were characterized by hyperinsluinemia(P <0.001) ,hypertriglycerisemia(P < 0.05 ), Insulin resistance (P <0.001). The results were associated with fatty liver disease. Conclusion: Liver disease is obviously associated with insulin Resi stance