溃疡性结肠炎患者血浆TXB2和6-酮-PGF1α的检测及意义

Detection and Significance of TXB2 and 6-Keto-pGF1α Levels in Patients with Ulcerative Colitis

目的 :探讨溃疡性结肠炎发病机制。方法 :应用RIA免疫法对30例溃疡性结肠炎(UC)患者血浆中TXB2和6 -酮 -PGF1α水平测定。结果 :UC患者血浆TXB2水平 ,TXB2/6-酮 -PGF1αX比值显著高于对照组。而6-酮 -PGF1α与对照组比较无统计意义。提示 :UC患者的血液流变性异常 ,机体相对处于高凝状态 ;UC时血小板功能较为亢进 ,导致血小板释放出更多的炎症因子 ,从而加重UC的发展 。

objective:To discuss the significance of serum TXB2 and 6-Keto-pGF1 α in Ulcerative Colitis disease.Methods:Serum TXB2 and 6-keto-pGF1 α were determined in 30 cases if TXB2 to 6-keto-pGF1 α were much higher in UC patients then the cotrol group,while the level of serum 6-keto-pGF1 had no signiflcant difference wifh control group,conclusion:With the disturbance of hemorheology,UC patient has a hypercoagulable condition,the hyprefunction of piatelet releases more inflammatory factors,and this promotes the development of UC disease,furthermore the complication of thrombogenie disease may occur.To UC patient,the abnormality of the TXB2 level or the ratio of TXB2 to 6-keto-pGF1 α could be regarded as an easy index.