皮肤成纤维细胞永生化的研究进展

The Progress of Study of Immortalized Skin Fibroblasts

正常体细胞的生命周期都是有限的 ,经过一定数目的分裂后 ,会进入增殖抑制状态。永生化细胞是近年来生物科学探索较多的领域之一。因为它不仅能为细胞生物学的研究提供性状稳定的研究对象 ,还为人类实现器官再生开辟了新方向。所以皮肤成纤维细胞的永生化对于皮肤疾病以及皮肤组织工程的研究都具有非常深远的意义。就皮肤成纤维细胞的永生化的研究作一阐述 。

Normal human cells have a finite capacity to replicate and eventually enter a state of irreversible growth arrest.Immortalization is not only the key events in neoplastic progression but also significant for tissues growth.Immortalized skin fibroblast may has a major impact in some of skin diseases and tissue engineering.The objective of this article is to review evidence for skin fibroblast immortalization.In addition,reconcile old observations with new molecular details and to focus attention on its influences in the future.