乙酰胆碱受体结构与功能的研究进展

The Recent Advances of the Structure and Function of Acetylcholine Receptor

乙酰胆碱受体是一种神经递质介导的离子通道受体 ,由 5个同源亚基组成。乙酰胆碱受体包括肌肉型和神经型两种。肌肉型乙酰胆碱受体是肌肉神经传导中的重要媒介物质以及自身免疫疾病重症肌无力的主要免疫原 ,神经型乙酰胆碱受体的突变也可导致某些疾病的发生。扼要介绍了近年来乙酰胆碱受体结构与功能的研究进展。

Acetylcholine receptor (AchR) comprised of five homogenous subunits is a kind of neurotransmitter gated ion channel receptor. It contains both the muscle type AchR and the neuronal type AchR. Muscle type AchR is an important medium of neuronal transmission and main immunogen of Myasthenia gravis,as well as some diseases were induced by the mutation of neuronal\|typed AchR. The recent advancesof the structure and function of acetylcholine receptor have been introduced in this article for the exploration of the mechanism of Myathenia gravis and other relevant diseases.