产泰对家兔在体子宫平滑肌收缩的影响

Effect of ChanTai on uterine constraction in normal and postpartum rabbits

目的 :观察产泰对正常及产后家兔在体子宫平滑肌收缩的影响 ,为其临床应用提供药理学实验依据。方法 :采用BL 3 1 0型生物机能实验系统 ,以家兔在体子宫收缩的频率、张力、活动力作为评价指标 ;阳性对照药采用了中医传统产后用药—生化汤丸 ,观察产泰对家兔子宫平滑肌收缩的作用。结果 :产泰高剂量组在给药 1 5分钟后就显著增强产后家兔在体子宫的活动力和平滑肌张力 (P <0 .0 1 ) ,且作用持续至给药后 1 2 0min ;中、低剂量组也能显著提高产后家兔的子宫活动力 (P <0 .0 1 ,P <0 .0 5 ) ;对正常家兔在体子宫的收缩 ,张力、频率、活动力产泰高剂量组在给药后的 75～ 1 2 0min也有促进其收缩的作用 (P <0 .0 5 )。结论 :产泰能明显提高家兔子宫收缩的张力和活动力 ,有利于产后子宫的复旧。

Objective: To study the pharmacological action of ChanTai in normal and postpartum rabbits. Methods: Using the BL 310 biological experimental system, to observe the frequency, the tension and the activity of the uterine constraction of the rabbits. Results: After 15 minutes the postpartum rabbits were given the high dosage of ChanTai, the activity and the tension of their uteruses significantly increased and lasted 120 minutes (P<0.01). The middle and low dosage of ChanTai could also increase of the activity of the postpartum uteruses (P<0.01, P<0.05). In normal rabbits, the high dosage of ChanTai had the same effect when it was given to the rabbits 75 minutes later (P<0.05). Conclusions: ChanTai can significantly increase the muscular constraction and the activity of the postpartum uterus of rabbits.