皮质激素联合宫腔内人工授精对免疫性不孕患者的治疗结果分析

THE APPLICATION OF CORTICAL HORMONE AND INTRAUTERINE ARTIFICIAL INSEMINATION IN THE TRATMENT OF FEMALE IMMUNE STERILITY

目的 探讨女性免疫性不孕患者的综合治疗方法。方法 选取抗精子抗体 (AsAb)、抗卵巢抗体 (AoVAb)、抗内膜抗体 (EmAb)、抗绒毛膜促性腺激素抗体 (hCGAb)阳性不孕妇女 189例 ,随机分为A、B两组。A组 (93例 ) ,单纯采用强的松周期疗法 ;B组 (96例 ) ,强的松 +宫腔内人工授精 (IUI)法周期治疗 ,分别于 1个疗程后 ,检测以上 4种抗体的转阴及妊娠情况。结果 A组 4种抗体转阴率达 88.7% ,B组 89.7%。经卡方检验无显著性差异。B组妊娠率为 5 4.2 %大于A组(35 .4 % ) ,差异有显著性 (P <0 .0 5 )。结论 皮质激素可以减少或消除免疫性不孕患者血清中抗体对妊娠各环节的影响 。

Objective To explore the comprehensive treatment of female immune sterility.Methods 189 sterility patients with AsAb(+),AoVAb(+),EmAb(+) and hCGAb(+) were divided in Group A(93 cases) and Group B(96 cases).Patients in Group A were simply treated with prednisone periodically.Patients in Group B were treated with prednisone and intrauterine artificial insemination periodically.Negative transformations of the above-mentioned antibodies and pregnancy were detected after a course of treatment.Results 88.7% of the antibodies in Group A and 89.7% in Group B were changed into negtive ones.χ 2 test showed no significant difference between the two groups.The pregnancy rate(54.2%) in Group A was higher than that (35.4%) in Group B(P<0.05).Conclusion Cortical hormone can reduce or eliminate the effects of serum antibodies on pregnancy in patients with immune sterility.The combined use of cortical hormone and intrauterine artificial insemination can obviously improve the pregnancy rate.