AKT-1在乳腺良恶性病变中的表达及其临床意义

Expression and Clinical Significance of AKT-1 in Benign and Malignant Lesions of Breast

目的:通过研究AKT-1在乳腺癌、癌旁正常组织、乳腺纤维腺瘤中的表达情况,探讨其在乳腺癌评估预后及治疗方面的价值。方法:采用免疫组化SP法,检测61例乳腺癌、20例癌旁正常组织、20例乳腺纤维腺瘤中AKT-1的表达情况。结果:AKT-1在乳腺癌旁正常组织中无表达,在纤维腺瘤中低表达(阳性率为15%),在乳腺癌组织中高表达(阳性率为49.2%),差异具有统计学意义(P<0.05)。在乳腺癌组中,AKT-1的阳性表达率与HER-2表达情况呈正相关;在原发灶大小不同、腋窝淋巴结有无转移和TNM分期不同组中,AKT-1的阳性表达率差异有统计学意义(P<0.05);在不同年龄、不同雌孕激素受体情况和不同组织学类型中,差异无统计学意义(P>0.05)。结论AKT-1可能是导致乳腺癌发生、发展的因素之一,在乳腺癌细胞向周围组织浸润,远处转移中起一定作用,对判断乳腺癌的恶性程度及预后有重要意义。

Objective:To explore the clinical values of AKT-1 in assessment of prognosis and treatment of breast carcinoma.Methods:The expression of AKT-1 in 20 cases of peritumoral tissue,20 cases of breast fibroadenoma and 61 cases of breast cancer were detected by immumohistochemical technique S-P.All the data were analyzed by using SPSS 17.0.Results:There was no expression of AKT-1 in normal mammary gland.There was a significant difference in the positive rates for expression of AKT-1 between the fibroadenoma and breast cancer(P<0.05).The positive expression rate of AKT-1 in breast cancer group had significant difference based on the sizes of the primary tumor.lymph node metastasis and different stages of TMN(P<0.05).The positive expression of AKT-1 had no difference between different ages\,hormone receptors and histological types(P>0.05).Conclusion AKT-1 plays an important role in promoting the process and invasion and metastasis of breast cancer,it could be used as one of indicators in evaluating prognosis of breast carcinoma.