滋水降火饮对肾性高血压大鼠血浆神经肽含量的影响

Influences of Zishui Jianghuo Yin(ZSJHY) on the Contents of Plasma Neuropepited in Renovascular Hypertensive Rates(RHR)

目的:研究肾性高血压大鼠血浆神经肽含量的改变,验证滋水降火饮的调节治疗作用。方法:用两肾一夹法制造大鼠肾性高血压模型,观察服用滋水降火饮引起血浆SP、CGRP、VIP含量的改变,分析该变化与cAMP、AngⅡ水平的关系。结果:肾性高血压大鼠血浆SP、CGRP、VIP含量明显降低,该变化与cAMP含量减少、AngⅡ水平升高有关,滋水降火饮(20、40g/kg)对以上改变有改善作用。结论:调节肾性高血压大鼠血浆神经肽含量、增加cAMP释放、降低AngⅡ水平可能是滋水降火饮发挥治疗作用的主要途径之一。

Objective: To research the changes of the contents of neuropepited in RHR and to evaluate the effects of ZSJHY. Methods: Renal arteries were constricted bilaterally with silver to induce RHR. The changes of ZSJHY on substance P(SP), Calcitonin Gene Related Peptide(CGRP)and Vasoactive Intestinal Polypeptide(VIP) in RHR were investigated. Correlations between this changes and cAMP Angiotensin (Ang II )were studied. Result: The contents of SP、CGRP、VIP in RHR were obviously decreased, which were related to increasing of cAMP and decreasing of Ang II. ZSJHY could correct the changes. Conclusion: Regulating the contents of plasma neuropepited, increasing the discharge of cAMP and decreasing the levels of Ang II may be one of mainly way of treatment by ZSJHY.