上海地区成人不同年龄组间CD4、CD8淋巴细胞计数正常值调查

Measurement of the CD4 and CD8 normal value range in adults from Shanghai area

目的 了解上海地区成人CD4、CD8计数及CD4/CD8比值正常参考值范围。方法 选取 6 14例成年人不同年龄组的血标本 ,根据不同性别、不同年龄组分别进行比较 ,用流式细胞仪进行CD4、CD8计数检测 ,得出不同性别及不同年龄组的CD4、CD8计数及CD4/CD8比值 ,并进行分析。结果 CD4正常值在不同性别及年龄组之间差异无显著性 ,其正常平均值为 72 6 .99± 2 5 5 .2 1。CD8及CD4/CD8在不同性别及其年龄组之间差异有显著性。CD8计数平均值为 5 39.98± 134 .0 7。CD4/CD8平均值为 1.49± 0 .5 7。结论 上海地区成人CD4淋巴细胞计数较国外低 10 0 /mm3 左右。对获得性免疫缺陷综合征CD4平均值的诊断临界值建议可采用 40 0 /mm3 。

Objective To measure normal range of CD4 from Chinese adults in Shanghai area by flow cytometry. Methods CD4 and CD8 value were measured through flow cytometry in adult blood specimens from various age and gender group. Results There were no difference in CD4 value among different sex and age groups, with the mean value being 726.99±255.21. However, CD8 and CD4/CD8 ratio vary significantly among different groups. The mean value of CD8 was 539.58±134.07, while the mean value of CD4/CD8 1.49±0.57. Conclusions The mean value of CD4 in Shanghai adults is about 100/mm 3 lower than that in American.