连续服用褪黑激素51天小鼠血液及肝部分生化指标的变化

Change of Chemical Indexes in Mice's Blood and Liver in Continuous Administration of MT during 51 Days

以雄性昆明种小鼠为实验对象,连续服用褪黑激素(MT)51d建立动物模型。分别测试血红蛋白(Hb)含量、血清谷丙转氨酶(SGPT)活性、血清谷草转氨酶(SGOT)活性、超氧化物歧化酶(SOD)活性、丙二醛(MDA)含量与总抗氧化能力(T-AOC)。结果表明,连续服用MT后,对小鼠Hb含量、肝SOD活性及SGOT活性无显著性影响(P>0.05),可使SGPT活性、血清及肝MDA含量显著下降(P<0.01)。肝T-AOC明显升高(P<0.05)。实验结果提示,MT具有很强的抗氧化能力,对机体的抗氧化系统有明显的辅助作用。

The objects were Kunming mice (♂). The model was set up by continuous administration of MT during 51 days. The indexes included the content of Hemoglobin(Hb) and Malondialdehyde(MDA), the activity of Glutamic-pyruvic Transaminase in serum(SGPT), Glutamin-oxalaceticTransaminase(SGOT) and Superoxide Dismutase(SOD) and Total anti -oxidant Capability(T-AOC). The results showed that continuous administration of MT did not significantly affect Hb content, the activity of SOD in liver and SGOT(P>0.05).The activity of SGPT and the content of MDA in liver and serum significantly decreased(P<0.01). But total anti-oxidation capability(T-AOC)significantly rose(P<0.05). Experimental results suggested that MT being strong in anti-oxidation capability could significantly assist anti-oxidation system of the body.