维持性血液透析伴认知功能障碍患者脑MRI影像学特点分析

Analysis of Brain MRI Imaging Features in Patients with Maintenance Hemodialysis and Cognitive Dysfunction

目的研究维持性血液透析(MHD伴认知功能障碍患者脑磁共振(MRI)影像学特点。方法将我院2016年1月-2018年1月间收治的31例MHD伴认知障碍患者纳为观察组,同时纳入50例健康体检者为对照组,分析两组脑MRI弥散张量成像(DTI)扫描影像学特点。结果观察组双侧额叶、双侧颞叶、双侧叶顶、双侧枕叶、双侧海马、双侧内囊前肢、双侧内囊后肢等感兴趣区域FA值均低于对照组,其中双侧额叶及双侧海马FA值差异显著(P<0.05);观察组左侧额叶FA值显著低于对照组(P<0.05)、右侧海马FA值显著低于对照组(P<0.05)。结论 MHD认知障碍者左侧额叶及右海马FA值显著低于常模,其左侧额叶及右侧海马易受到损坏,脑白质神经纤维束完整性差。

Objective To study the of imaging features of brain magnetic resonance imaging(MRI) in patients with maintenance hemodialysis(MHD) and cognitive dysfunction.Methods 31 cases of patients with MHD and cognitive dysfunction admitted to our hospital from January 2016 to January 2018 were enrolled in observation group, and another 50 healthy examiners were included in control group. The scanning imaging features of brain MRI cranial diffusion tensor imaging(DTI) were analyzed in the two groups. Results The FA values of regions of interest of bilateral frontal lobe, bilateral temporal lobe, bilateral apical lobe, bilateral occipital lobe, bilateral hippocampus, bilateral internal capsule forelimb and bilateral internal capsule hind limb in observation group were lower than those in control group, and the FA value of bilateral frontal lobe and bilateral hippocampus was significantly different(P<0.05). The FA value of left frontal lobe in observation group was significantly lower than that in control group(P<0.05). The FA value of right hippocampus was significantly lower than that in control group(P<0.05). Conclusion The FA values of left frontal lobe and right hippocampus of patients with MHD and cognitive dysfunction are significantly lower than those in normal model, and its left frontal lobe and right hippocampus are vulnerable to damage, and the nerve fiber bundle of white matter is with poor integrity.