MRI-PWI对脑梗死前期患者微循环状态评价的研究

MRI-PWI Study on the Evaluation of Microcirculation Status in Patients with Preinfarction Cerebral Infarction

目的脑梗死前期患者微循环状态应用MRI灌注成像进行评价的临床意义。方法纳入于2018年5月-2019年1月就诊于我院神经内科的症状性脑卒中患者55例,行常规MRI检查,对DWI图像为阴性的患者进一步行MRI-PWI成像,测量患者患侧与健侧的rCBF、rCBV、MTT及TTP参数值并进行对比分析。结果本组纳入的55例患者中,16例MRI-DWI结果为阴性,进行MRI-PWI成像发现其中12例脑内有低灌注区域,其中Ⅰ1期5例、Ⅰ2期2例、Ⅱ1期3例、Ⅱ2期2例,患侧与健侧对比,rCBV、rCBF、MTT、TTP差异均具有统计学差异(P<0.05)。结论 MRI-PWI成像与MRI-DWI相比,对脑梗死前期病变的检出率更高,为缺血性脑卒中患者的早期诊断提供重要依据。

Objective To evaluate the clinical value of MRI perfusion imaging in microcirculation status of patients with pre-infarction.Methods fifty-five symptomatic stroke patients admitted to the department of neurology of our hospital from may,2018 to January,2019 were included.Routine MRI examination was performed.Patients with negative DWI images were further imaged with MRI-PWI,and the values of rCBF,rCBV,MTT and TTP parameters on the affected side and the uninjured side were measured and compared.Results among the 55 patients included in this group,16 of them had negative MRI-DWI results.MRI-PWI imaging found 12 cases by MRI brain hypoperfusion area,includingⅠ1 period in 5 cases,Ⅰ2 period in 2 cases,Ⅱ1 period in3 cases,Ⅱ2 period in 2 cases.The differences in rCBV,rCBF,MTT and TTP between the affected side and the healthy side were statistically significant(P<0.05).Conclusion compared with MRI-DWI,MRI-PWI has a higher detection rate of preinfarct lesions.It provides important basis for early diagnosis of ischemic stroke.