血清PCT、IL-6检测联合CT检查对新生儿肺炎的早期诊断价值分析

Value of Serum PCT and IL-6 Combined with CT in Early Diagnosis of Neonatal Pneumonia

目的探讨血清降钙素原(PCT)、白介素-6(IL-6)检测联合CT检查对新生儿肺炎的早期诊断价值分析。方法选取2017年1月至2018年3月我院收治的69例新生儿肺炎患者为观察组,另外选取健康足月儿30例为健康对照组,比较两组新生儿PCT、IL-6水平,总结新生儿肺炎CT平扫图像表现,并计算不同检查方式对新生儿肺炎的早期诊断灵敏度和特异度。结果观察组新生儿血清PCT、IL-6水平明显高于对照组,差异具有统计学意义(P<0.05);CT平扫+PCT+IL-6检查对新生儿肺炎的早期诊断灵敏度和特异度分别为94.61%、91.80%,明显高于PCT、IL-6、CT平扫、PCT+IL-6、CT平扫+PCT、CT平扫+IL-6检查,差异具有统计学意义(P<0.05);69例新生儿肺炎患者CT平扫的图像主要出现肺纹理增多、边缘模糊,多数患者出现斑块状高密度影,肺门不同程度增宽、变厚,出现实变影者31例,病灶直径较小,同时合并支气管充气征。结论血清PCT、IL-6检测联合CT检查新生儿肺炎的早期诊断灵敏度和特异度高。

Objective To explore the value of serum procalcitonin(PCT),interleukin-6(IL-6)detection combined with CT in early diagnosis of neonatal pneumonia.Methods 69 cases of neonatal pneumonia in our hospital from January 2017 to March 2018 were selected as the observation group,and 30 healthy full-term infants as the healthy control group.The levels of PCT and IL-6 were compared between the two groups,and the CT plain scan images of neonatal pneumonia were summarized.The sensitivity and specificity of different examination methods for early diagnosis of neonatal pneumonia were calculated.Results The levels of serum PCT and IL-6 in the observation group were significantly higher than those in the control group(P<0.05).The sensitivity and specificity of CT plain scan+PCT+IL-6 for early diagnosis of neonatal pneumonia were 94.61%and 91.80%,respectively,which were significantly higher than those of PCT,IL-6,CT plain scan,PCT+IL-6,CT plain scan+PCT,CT plain scan+IL-6,with specific statistical significance(P<0.05).In 69 cases of neonatal pneumonia,plaque-like high-density shadow was found in most cases.The hilum was widened and thicker in varying degrees.Thirty-one cases had consolidation,and the lesion was small in diameter,accompanied by bronchial inflation.Conclusion Detection of serum PCT and IL-6 combined with CT has high sensitivity and specificity in early diagnosis of neonatal pneumonia.