门静脉高压症胃黏膜血管内皮生长因子的变化

<title>Changes of vascular endothelial growth factor in the gastric mucosa in portal hypertensive gastropathy

目的 探讨血管内皮生长因子(VEGF)在门静脉高压性胃病变(PHG)中的作用。方法 分析44例肝硬化门静脉高压症病人的PHG发生率,病变部位和严重程度,以及病变部位VEGF的变化。结果 PHG者胃黏膜VEGF明显高于无胃病者及对照组(P<0.01),其中重度胃病者VEGF明显高于轻度胃病者(P<0.01)。结论 VEGF可能是造成PHG胃黏膜损害的重要因素之一。

<Abstrcat>Objective To study the effect of vascular endothelial growth factor(VEGF) on portal hypertensive gastropathy(PHG). Methods The incidence,location, and severity of PHG and the changes of VEGF in PHG were analysed in 44 cases. Results VEGF in the severe or moderate PHG group was significantly higher than that in the control group and in patients with portal hypertension without PHG(all P<0.01). VEGF in the severe PHG parients was significantly higher than that in the moderate PHG parients. Conclusions VEGF may play an important role in the development of PHG.