赛庚啶对糖尿病黎明现象的作用

EFFECT OF CYPROHEPTADINE ON "DAWN PHENOMENON" OF DIABETES MELLITUS

作者观察了40例糖尿病患者1a.m.及7a.m.血糖、生长激素及皮质醇的变化,对18例患者采用赛庚啶治疗,探讨了赛庚啶对糖尿病患者黎明现象的作用。结果表明:糖尿病患者7a.m.血糖、生长激素及皮质醇高于1a.m.。赛庚啶可使7a.m.血糖、生长激素及皮质醇降低。提示糖尿病清晨血糖升高与生长激素、皮质醇水平升高有关,服用赛庚啶可防治糖尿病黎明现象。

Scrum glucose, growth hormone and cortisol were determined at 1 a.m. and 7 a.m. in 40 patients with diabetes mel-litus. 18 cases were treated with cyproheptadine. Effect of cyproheptadine on 'dawn phenomenon' of diabetes mel-litus was observed. The results showed that serum glucose, growth hormone and cortisol were higher at 7 a.m than at 1 a.m. Cyproheptadine could significantly decrease 7 a.m. serum glucose, growth hormone and cortisol. Those data suggested that diabetic dawn phenomenon has concern with the increase of growth hormone and cortisol level and cyproheptadine can be used for preventing and treating this dawn phenomenon.