人胎儿脑细胞核T_3及其受体的个体发生

ONTOGENESIS OF HUMAN FETAL BRAIN NUCLEAR T_3 AND ITS RRECEPTO

本文报告了对胎儿脑细胞核T_3及其受体的个体发生进行的系统研究实验结果。实验结果表明:(1)胎儿的大、小脑细胞核受体对T_3的亲和常数(Ka)值不因脑区不同或发育阶段不同而有显著差别;(2)胎儿大、小脑细胞核T_3受体的最大结合容量(MBC)值有所不同,但均随孕龄增加而增高,且各呈线性相关;(3)胎儿脑细胞核内源T_3含量(总量及受体结合形式者)随发育而增高,且与受体MBC值的增长显著相关;(4)受体占位率不随发育而改变。

In this study, conditions for storage of specimen and analyses of human fetal brain nuclear endogenous T, and its receptor were established. By analyzing 23 fetal brains with the stage of gestation from 12 to 36 weeks, the results showed that: 1) the affinity constants, Ka of receptor to T3 in cerebra and cerebella of human fetus of different gcsta- tional stages were not different significantly: 2) the maximum binding capacities of receptor for T, were different in cerebrum and cerebellum, and both increased with the gestational stage, i.e., correlated positively and linearly with the latter; 3) the same situation was found for the nuclear endogenous T3 in cerebrum and cerebellum; 4) based on the data obtained, the regression equation for cerebrum nuclear endogenous T3, MBC of its receptor and the gestational stage was derived by three-variant regression analysis, and 5) the occupancy of fetal cerebrum nuclear T3 receptor did not change significantly with the gestational stage.