儿童肾脏病合并水痘-带状疱疹病毒感染的防治

Varicella-zoster virus infection in children with kidney diseases:prevention and treatment

目的 :探讨儿童肾脏病合并水痘 -带状疱疹病毒感染的治疗和预防。方法 :分析合并水痘感染的 10例肾脏病患儿 ,其中微小病变型 3例 ,系膜增殖性肾小球肾炎 6例 ,系膜增殖性伴新月体形成 1例 ;有中轻度水痘感染者 9例 ,重度水痘感染者 1例。用干扰素无环鸟苷、丙种球蛋白或血浆、鲜血、血小板悬液治疗 7d。结果 :9例治愈 ,1例死亡。 10例患儿实验室检查IgG、C3、C4 均低下。结论 :肾脏病患儿免疫功能低下 ,应用糖皮质激素等免疫抑制剂和细胞毒类药物后 ,易感染水痘病毒 ,应用干扰素、无环鸟苷等治疗有效。

Objective:To investigate the prevention and treatment of varicella-zoster virus infection in children with kidney disease.Methods:Ten varicella infection in children with kidney disease were analysed. Three had minimal changes, 6 had mesangial proliferative glomerulonephritis, and 1 had memberanoproliferative glomerulonephritis with crescent. Nine patients had slight or moderate varicella infection, and 1 had severe infection. They were treated with interferon, acyclovir, γ-globulin or plasma, fresh blood and platelet suspension for 7 days. Results:Nine patients were cured and 1 died. Furthermore, serum IgG, C 3 and C 4 decreased in all the children in the laboratory tests. Conclusion:The children with kidney disease are immunodeficient. They are susceptible to the varicella viruses after the administration of steroids. Interferon, acyclovir or γ-globulin are effective in the treatment.