安雄对去势大鼠离体阴茎海绵体平滑肌舒张性的影响

The Effects of Testosterone Undecanoate on Relaxation of Rat Corpus Cavernosum Smooth Muscle in vitro

目的 :探讨口服雄激素类药安雄对大鼠阴茎海绵体平滑肌舒张性的调节作用。 方法 :去势大鼠分别给予高、低剂量的安雄 ,与假手术组、去势组大鼠进行对照观察。治疗 4周后分别切取其阴茎海绵体 ,制成海绵体肌条 ,应用去甲肾上腺素对海绵体肌条进行预收缩 ,继予硝普钠 (SNP)、电刺激 (EFS)观测海绵体平滑肌的舒张性 ,比较各组的舒张百分率。 结果 :高剂量安雄 (2 0mg/kg)组其离体平滑肌条 ,对 10 -3 mol/LSNP和EFS的舒张百分率高于去势组 ;低剂量组 (10mg/kg)对 10 -3 mol/LSNP诱导的舒张百分率也高于去势组。统计学处理差异有显著性 (P <0 .0 1) , 结论 :去势大鼠应用安雄可提高离体大鼠海绵体平滑肌的舒张百分率 。

Objectives: To investigate the role of Undecanoate (Andriol), as a kind of testosterone, in regulating the relaxation of isolated rat corpus cavernosum in vitro . Methods: The castrated rats were given high and low dosage Andriol respectively,compared with intact and castrated rats. After treatment of 4 weeks, the corpora cavernosa were cut, trimmed as to strips. Norepinephrine(NE) was added to contract each of the tissue strips. Next, sodium nitroprusside(SNP), electric functional stimulation(EFS) were used to relax the strips . Percent relaxations were examined. Results: High dose Andriol(20 mg/kg) was significantly effective to castrated rats on percent relaxation induced by 10 -3 mol/L SNP and EFS. Low dose Andriol(10 mg/kg) was also effective to relax strips induced by 10 -3 mol/L SNP. According to statistics, the differences were significant ( P <0.01). Conclusions: The percent relaxations of castrated rats were increased after taking Andriol, and it could increase the relaxation of corpara cavernosa.