从气虚毒瘀探讨自噬在糖尿病肾病中的作用

Discussion on the Role of Autophagy in Diabetic Nephropathy Based on the Theory of “Qi Deficiency, Toxic Stasis”

糖尿病肾病(DN)是糖尿病(DM)的严重并发症之一,目前尚缺乏有效的治疗手段。自噬作为机体的主要防御机制之一,在维持肾环境的稳定中发挥重要的作用,对于DN也同样重要。自噬参与糖尿病肾病的病理生理过程,饮食不节是细胞自噬与早期糖尿病肾病的共同病因。细胞自噬与中医"气虚毒瘀"理论有很多相似之处,现就自噬在DN发生、发展中的作用以及中医"气虚毒瘀"理论与细胞自噬如何参与早期糖尿病肾病的微观病理生理机制做相关探讨,为糖尿病肾病的中医药防治提供新的思路和方法。

Diabetic nephropathy(DN)is a serious complication of diabetes mellitus(DM),and there is none effective treatment at the moment.Autophagy,as one of the main defense mechanisms of the body,plays an important role in maintaining kidney homeostasis,as well as in DN.Autophagy is involved in the pathophysiological process of DN.Irregular diet is the common cause of cell autophagy and early DN.There are many similarities between cell autophagy and TCM theory of'qi deficiency,toxic stasis'.In this paper,the role of autophagy in the occurrence and development of DN and how autophagy participates in the micro-pathophysiological mechanism of early DN is discussed,which provides new ideas and methods for the prevention and treatment of DN in TCM.