PCT在不同基础疾病发生感染时的应用评价

Evaluation of the Application of PCT in the Occurrence of Infection in Different Basic Diseases

目的探讨降钙素原(PCT)在肺炎与慢性阻塞性肺疾病急性加重期(AECOPD)的诊断价值,评估在不同基础疾病发生感染时变化及意义。方法将正常组、COPD组注入灭菌生理盐水后进行比较,将正常组、COPD组分别注入铜绿假单胞菌、肺炎链球菌后进行比较,比较大鼠体内注入不同菌液24 h内2组血清PCT的水平。结果正常组血清PCT与COPD组PCT同一时间点两两比较具有统计学意义(P <0.05);肺炎铜绿组PCT与AE铜绿组PCT同一时间点两两比较具有统计学意义(P <0.05);肺炎肺链组血清PCT与AE肺链组PCT同一时间点两两比较具有统计学意义(P <0.05)。结论检测血清PCT水平对于诊断肺炎和慢性阻塞性肺疾病急性加重期(AECOPD)有重要的指导意义。有助于区分不同基础疾病发生感染时,PCT水平变化具有差异性且有意义。

Objective To investigate the diagnostic value of PCT in patients with pneumonia and acute exacerbation of chronic obstructive pulmonary disease(AECOPD),and to evaluate the changes and significance of PCT in infection with different underlying diseases.Methods The normal group and COPD group were injected with sterilized saline,the normal group and COPD group were injected with pseudomonas aeruginosa and streptococcus pneumoniae respectively.Results Serum PCT in normal group and PCT in COPD group was statistical significance in pairwise points(P<0.05).PCT in bronzed green group and in AE aeruginosa group was significant difference in time points(P<0.05).Serum PCT in pneumonia pulmonary chain group and AE lung chain group was significant difference between two groups at the same time point(P<0.05).Conclusion Detection of serum PCT level is of great significance in the diagnosis of pneumonia and acute exacerbation of chronic obstructive pulmonary disease(AECOPD).It is helpful to distinguish the changes of PCT levels in different basic diseases.