珍枣胶囊治疗静止性脑梗死

Zhenzao Capsule in the Treatment of Silent Cerebral Infarction

目的分析静止性脑梗死患者失眠的特征及与认知障碍的相关性,探讨珍枣胶囊治疗静止性脑梗死患者失眠、改善认知功能的疗效。方法利用匹兹堡睡眠质量指数量表(PSQI)对120例静止性脑梗死患者进行睡眠质量评估,将患者分为失眠组和非失眠组,对2组患者进行简易智能精神状态量表(MMSE)评估,比较2组患者认知障碍的发生率。对辨证为阴虚火旺证的失眠组患者进行4周的珍枣胶囊治疗,比较治疗前后PSQI、MMSE评分情况。结果纳入研究的脑梗死患者中,79例(65.83%)发生失眠,失眠的形式以潜伏期延长、维持障碍、质量下降为主。失眠组MMSE评分明显高于非失眠组,认知功能障碍发生率高于非失眠组。阴虚火旺证的失眠患者经珍枣胶囊治疗后,PSQI评分较治疗前显著降低,MMSE评分较治疗前明显提高。结论失眠在静止性脑梗死患者中的发生率较高,并且与认知障碍有一定的相关性,早期给予珍枣胶囊干预治疗,可改善患者的睡眠质量,减轻认知障碍症状。

Objective To analyze the correlation of insomnia and cognitive impairment after silent cerebral infarction,and to explore the ef fect of Zhenzao Capsule on insomnia and cognitive improvement in patients with static cerebral infarction.Methods A total of 120 patients with silent cerebral infarction were randomly selected and all patients were assessed for sleep quality with the Pittsburgh Sleep Quality Index(PSQI).The patients were divided into insomnia group and non-insomnia group.Both groups were assessed by simple intelligent mental state examination(MMSE),and the incidence of cognitive impairment was compared between the two groups.The insomnia patients with syndrome of exuberant fire due to yin deficiency were treated with Zhenzao Capsule for 4 weeks,and the scores of PSQI and MMSE before and after treatment were compared.Results Insomnia occurred in 79 patients(65.83%).The main causes of insomnia were difficulty in falling asleep,early awakening,and difficulty in maintaining sleep.The MMSE score of insomnia group was significantly higher than non-insomnia group,the incidence of cognitive dysfunction was higher than non-insomnia group.The PSQI score of insomnia patients treated with Zhenzao Capsule was significantly lower than that before treatment,and the MMSE score was significantly higher than that before treatment.Conclusion The incidence of insomnia is higher in patients with static cerebral infarction,and has a certain correlation with cognitive dysfunction.Early treatment with Zhenzao Capsule can improve the quality of sleep and reduce the symptoms of cognitive dysfunction.