溴隐亭对脑垂体腺瘤的作用——19例临床病理研究

Effect of bromocriptine on pituitary adenomas

12例催乳素腺瘤(PRL 腺瘤)和7例生长激素腺瘤(GH 腺瘤),手术前服溴隐亭治疗,摘除标本进行光镜、电镜、免疫组化等研究,另外各有7例手术前未服药的手术标本同样观察以为对照研究。结果:PRL 腺瘤细胞明显缩小,主要是粗面内质网、高尔基氏器核糖体等减少以致瘤体积缩小、故认为溴隐亭主要是抑制泌乳素腺瘤的泌乳激素产生和释放,并无根治和杀伤瘤细胞的作用。

Bromocrptine(BC)has been shown to producesignificant shrinkage of secreting pituitary tumors.In order to evaluate the effect of BC,we report19 patients with pituitary macroadenomas 10mm indiameter).The diagnosis were established by CTand endocrine assay.They were treated with BCfor a period of 16-52 days(mean 25 days),andthen adenomas were enucleated through transsphenoidoperation.Histopathological.ultrast ructural andimmunocytochemical features were investigatedIn the group A,there were 12 patients withprolactinomas demonstrated by immunocytochemicalPAP method.All of which the size of the tumorswere reduced.The patients revealed reduction ofserum prolactin levels and some manifested reliefof symptoms during BC therapy.Pathologically,thetumor cells of the group A were smaller thangroup B(7 cases with GH secreting adenomastreated with BC).Electron microscopically,group A tumor cellswere reduced in size,It was due to reduction ofcytoplasmic volume,resulting from ribosome,roughendoplasmic reticulum and Golgi complexes.Thesecretory granules in the cytoplasms were sparse.Neither widespread cell necrosis and infarction,norvascular injury were observed.The mechanism ofBC on prolactin-secreting pituitary tumor isdisscused.