摘要
为进一步了解心理因素诱发、加重银屑病的物质基础,我们采用RIA 测定49 例银屑病患者和34 名正常人血清对正常小鼠淋巴细胞转化的影响和NIP单克隆抗体对抗银屑病患者血清的抑制作用的试验。结果表明银屑病患者血清中有抑制正常小鼠淋巴细胞转化的物质,进行期患者血清中的抑制作用大于静止期,皮损面积愈大者其血清对小鼠淋巴细胞转化率的抑制作用愈强(P< 0.001,r=0.4939);进一步研究表明银屑病患者血清中抑制淋巴细胞转化的主要物质与NIP类似。
In order to find out the material base of the induction and aggravation of psoriasis by psycological factors,we have determinated with radioimmunoassay the effect of NIP to suppress lymphocyte transformation in serum from 49 psoriatic patients and 34 healthy conrols.The results showed that the action to suppress lymphocyte tranformation in psoriatic patients are stranger than that in healthy controls;the suppresive effect of serum in patients during progressive stage and with greater lesion area are stranger than that during the stable stage and with smaller lesion area ( P<0.001,r=0.4939 ).Futher study suggests that the substance is similar to NIP,which is neutralized by NIP monoclonal antibady added to the psoriatic serum.But the the cause and effect relationship between the NIP and the pathogenesis of psoriasis needs more study.
出处
《空军总医院学报》
1998年第1期1-3,共3页
Journal of General Hospital of Air Force,PLA
关键词
放射免疫法
银屑病
血清
神经免疫蛋白
淋巴细胞转化
Psoriasis Radioimmunoassay(RIA) Neurotisstue proteins Lymphocyte transformation