活血化瘀中药对激素性股骨头坏死血浆TXB_2与6-keto-PGF_(1α)影响的实验研究

Experimental study of the influence of blood-circulation-activating traditional Chinese drugs on plasma TXB_2 and 6-keto-PGF_(1α) of glucocorticoid induced femoral head necrosis

目的 探讨活血化瘀法在激素性股骨头坏死的治疗作用。方法 用内毒素加激素注射造成兔股骨头坏死 ,测定其血浆TXB2 和 6 keto PGF1α的动态变化 ,以此作为血瘀证的观察指标。结果 光镜观察示模型组股骨头骨小梁变细、空骨陷窝增加 ,成骨细胞数量减少 ,并出现TXB2 与 6 keto PGF1α比值失平衡 ,这些表现随着时间的推移逐渐加重 ;而用复方生脉成骨胶囊治疗能逆转股骨头坏死 ,保护血管内皮 ,恢复TXB2 与 6 keto PGF1α的平衡。结论 激素性股骨头坏死与血瘀证之间有密切关系 ,用活血化瘀中药可防止股骨头坏死的发展。

Objective To explore the therapeutic effects of blood circulation activating method on glucocorticoid induced femoral head necrosis (GANFH) Methods Rabbit models of GANFH were made by injecting endotoxin and methylprednisolone.Plasma TXB 2 and 6 keto PGF 1α were used as the objective indices for observing blood stasis.Results Light microscopy showed empty lacunae increased and numbers of osteoblasts and subchondral sinosoids decreased in model group;ratio of TXB 2 and 6 keto PGF 1α was out of balance.These changes were worsened with progress of the disease.Fufang Shengmai Chenggu Capsule could protect the vascular endothelial cells,recover the balance of TXB 2 and 6 keto PGF 1α ,which further reverse GANFH.Conclusion There is a closed relationship between GANFH and blood stasis.Blood circulation activating method may be beneficial for the reparative process of necrosis of the femoral head.