脾大部栓塞治疗儿童遗传性球形红细胞增多症

Partial Splenic Embolization for the Treatment of Hereditary Spherocytosis in Children

目的 评价脾大部栓塞术治疗遗传性球形红细胞增多症 (HS)的效果和优势 ,并作文献回顾。资料与方法 6例HS患者行经脾动脉脾大部栓塞术。比较患者术前及术后相关指标。结果 脾栓塞量为 70 %～ 80 %。患者术后血红蛋白浓度明显上升 ,网织红细胞计数明显下降 ,血清胆红素浓度迅速恢复正常 ,脾脏缩小 ,患者术后体力和精力均明显改善 ,免疫功能无损害 ,随访期间无严重感染发生。结论 经脾动脉脾大部栓塞术是治疗HS的有效方法 ,安全 ,损伤小 。

Objective To evaluate percutaneous splenic artery embolization (PSE) in treating hereditary spherocytosis (HS). Materials and Methods Six patients with HS were treated with PSE. The related indexes and clinical situation before and after PSE were collected and compared.Results The embolized volume of the spleen was up to 70%～80%. After PSE, the HGB concentration increased and reticulocyte count dropped markedly, while the size of the spleen reduced. Patient's physical strength and stamina became obviously improved. No immunological damage was seen and no serious infection occurred during follow up period.Conclusion PSE is an effective, safe and mini invasive procedure to treat HS, besides, the immunological function of the spleen can be reserved.