多孔微晶玻璃作为缓释药物载体的体外实验研究

IN VITRO DRUG RELEASE BEHAVIOR OF CARRIER MADE OF POROUS GLASS CERAMICS

目的 探讨多孔微晶玻璃材料作为载体 ,对利福平药物进行包裹。通过体外释放实验 ,分析影响载体释药速率的主要因素。方法 将玻璃结晶制备得到的各种短纤维状磷酸钙晶体压制成中空圆柱状的多孔材料 ,封装一定量的利福平后浸泡在生理模拟液中 ,检测浸泡液中的药物浓度。结果 利福平能以恒定的速度、较长时间内自多孔微晶玻璃制成的缓释药物载体中释放 ,并且释放速度取决于微晶玻璃纤维的大小和载体的厚度。

Objective To conduct the in vitro test on drug release of rifampin encapsulated in a carrier made of porous phosphate glass ceramics and to analyze main factors which affect the drug release rate.Methods A certain quantitative of rifampin was sealed in a hollow cylindrical capsule which consisted of chopped calcium phosphate crystal fiber obtained from glass crystallization. The rifampin concentration was measured in the simulated physiological solution in which the capsule soaked. Results Rifampin could be released in a constant rate from the porous glass ceramic carrier in a long time. The release rate was dependent on the size of crystal fiber and the wall thickness of the capsule. Conclusion This kind of calcium phosphate glass ceramics can be a candidate of the carrier materials used as long term drug therapy after osteotomy surgery.