碱性成纤维细胞生长因子在肛周创面愈合中的疗效观察

CURATIVE EFFECTS OF BASIC FIBROBLAST GROWTH FACTOR ON ANUS WOUND HEALING

目的 观察碱性成纤维细胞生长因子 (b FGF)对肛周疾病术后创面愈合的影响。方法 1996年 4月～2 0 0 0年 12月 ,因肛周外伤、痔疮及肛瘘手术后 10 9例 ,其中 6 8例局部应用 b FGF,4 1例常规换药法治疗的肛周术后创面的愈合、全身及局部反应情况进行观察。结果 应用 b FGF治疗组肛周术后创面的愈合时间为 (17.0 0± 1.5 4 )天 ,局部疼痛轻 ,3周内愈合率 97.1% ;常规治疗组肛周术后创面的愈合时间为 (2 0 .0 0± 1.16 )天 ,换药时局部剧痛 ,3周内愈合率87.8% ,两组的愈合时间与愈合率比较均有统计学意义 (P<0 .0 1) ,两组均未见肝、肾功能异常及过敏反应。结论 局部外用 b FGF可加速创面的愈合过程 ,患者痛苦少 。

Objective To observe the curative effects of basic fibroblast growth factor (bFGF) on anus wound healing. Methods From April 1996 to December 2000, out of 109 patients with anus trauma, hemorrhoidectomy or fistula resection, 68 were treated with bFGF as the experimental group, while 41 were treated routinely as the control group. The healing of the wound, the general and local reaction were observed. Results The healing time of the experimental group was(17 00±1 54) days while that of the control group was(20 00±1 16) days ( P< 0.01). Three weeks after operation, the healing rates of the experimental and control groups were 97.1% and 87.8%, respectively ( P< 0.01). No general or local detrimental reactions were found in two groups. Conclusion Local application of bFGF can accelerate the healing of anus wound, and the patients have little pain.