脱钙牙基质在骨修复中的应用

APPLICATION OF DECALCIFIED DENTAL MATRIX IN BONE REPARATION

目的 探讨脱钙牙基质 (DDM)对创伤性骨折愈合的促进作用和毒副作用。方法 1997年 6月～1998年 12月 ,对外伤性 3周内四肢闭合性长管骨骨折患者 4 2例 ,随机分成应用组和对照组 ,每组 2 1例 ,行相同的骨折切开复位内固定 ,应用组植入 DDM,对照组不植入 DDM。观察术后体温、谷丙转氨酶测定、骨折愈合时间及切口愈合情况。结果 4 2例患者随访 1～ 3年。应用组骨愈合时间 6～ 2 0周 ,平均 12 .76周 ,对照组骨愈合时间 10～ 2 4周 ,平均 17.8周 ,两组间有统计学意义 (P<0 .0 1) ;体温变化无差异 (P>0 .0 5 ) ;术后 1周谷丙转氨酶测定两组均无升高 ,无差异 (P>0 .0 5 ) ;切口均无感染 ,局部无积液。结论 DDM有促进骨痂生长作用 ,能加速骨折愈合 。

Objective To investigate the effect of decalicified dental matrix (DDM) on healing of traumatic fracture and its side effect. Methods From June 1997 to December 1998, 42 patients with closed traumatic long bone fracture (36 males and 6 females, aged from 18 to 57 years with an average of 32 years) were divided into two groups randomly; open reduction and internal fixation were carried out in all patients, but the DDM was used only in experimental group. After operation, the body temperature, ALT, and bone union time were observed and recorded. Results Following up 1 to 3 years, the bone union time of experimental group was significantly shorter than that of control group ( P< 0.01), there was no significant difference in the temperature and ALT changes between two groups( P> 0 05). No infection occurred. Conclusion DDM can promote the growth of bony callus and enhance the healing of fracture. There is no side effect.