轻度低温治疗重症颅脑损伤

Effect of mild hypothermia in patients with severe traumatic brain injury

目的 探讨 3 5℃± 0 .5℃的轻度低温水平对重症颅脑损伤的治疗效果。方法 对 2 2例GCS为 8分以下重症颅脑损伤患者在常规治疗基础上实施肛温为 3 5℃± 0 .5℃轻度低温治疗 ,并与 45例常规治疗组对照观察 ,观察其预后、血糖水平、并发症情况。结果 治疗组良好率 3 6.4% ,对照组为 2 6.7% (P <0 .0 1) ,血糖水平控制优于对照组 (P<0 .0 5 ) ,并发症发生情况两组无明显差异 (P >0 .0 5 ) ,未发生心律失常、顽固的上消化道出血以及复温时的反跳性高热、休克等不良反应。结论 3 5℃± 0 .5℃的轻度低温水平对重症颅脑损伤具有良好的治疗效果。

Objective To investigate the effect of mild hopythermia in patients(35℃±0.5℃) with severe traumatic brain injury. Method Twent-two patients suffered from severe traumatic brain injury(GCS scores 3-8) were treated with conven-tional therapy and mild hopythermia;meanwhile,forth-five patients suffered from severe traumatic brain injury(GCS scores 3-8) were treated with conventional therapy only. Prognosis?blood sugar and complications were observed. Results Good recovery was 36.4% in hopythermia group,and 26.7% in control group( P <0.01). Hyperglycemia of hopythermia group decreased significantly compared with that of control group( P <0.05). Complications hed no significant difference betwean groups. And arrhythmia?obstinaled upper digestive tract hemorrhage?rebound hyperthermia and shock didit occur. Conclusion Hopythermia(35℃±0.5℃) is effective in preventing brain damage.