新颖手性胺基膦配体在烯胺不对称催化氢化反应中的应用(英文)

Application of Novel Chiral Aminophosphine Ligand in Asymmetric Catalytic Hydrogenation of Enamides

将新颖的手性胺基膦配体 ,6 ,6’_二甲氧基 - 2 ,2’_双 (二苯胺基膦 ) - 1,1’_连苯的铑络合物应用于烯胺类化合物的不对称催化氢化反应中 ,发现这个铑络合物是一个有效的手性催化剂 ,各种手性胺产物的转化率为10 0 % ,光学选择性 (ee)也达到了 5 1%～ 43% .

The rhodium complex of novel chiral aminophosphine ligand 6,6'-dimethoxy-2,2'-bis(diphenylphosphinoamino)-1,1'-biphenyl was found to be an effective catalyst for the asymmetric hydrogenation of enamides with product ee's ranging from 51% to 43% and 100 % conversion.