环境微量元素对甘肃河西地区胃癌发病的影响

Impact of Environmental Trace Elements on Gastric Cancer in Hexi Region, Gansu Province, China

环境物质中的微量元素水平与胃癌之间存在相关联系 ,甘肃省是胃癌高发区 ,对甘肃省河西地区胃癌患者生活饮用水及土壤微量元素进行了相关性研究 .结果表明 :河西地区水土的Fe含量高于对照组 ,高浓度游离Fe有利于癌细胞的快速繁殖 ,摄入高浓度的离子Fe对机体有毒害作用 ,是导致胃癌发生的一个重要因素 .环境中Zn水平低可能是胃癌发生的癌前因素 ,Se水平与癌症生病率呈负相关 ,河西地区环境中镓含量较低 ,可能导致机体内微量元素的不平衡 。

The gastric cancer has been higher in malignant tumor for many years. Factors of gastric cancer have lots of aspects, environment and diet customs are important on progressing of gastric cancer. Hexi area is an area of high disease incidence; the study on trace elements in environment is paid close attention to for exploring diseases cause of gastric cancer. Gastric cancer occurred by more factors together, the changing of some trace elements in environment is relative with gastric cancer. we took the samples in 13 countries of the Hexi region as gastric group, including 70 water samples and 70 soil samples, and took Tianshui city samples as comparison group, then determined 13 kinds trace elements by ICP AES. The result indicate that Fe and Al of water and soil samples are higher in gastric group ( P <0 05), the lower are Zn?Ga?Se of soil samples( P <0 05), Ca?Zn?Ga?Sr?Se of water samples( P <0 05). The element changes of water and soil in Hexi area have relationship with gastric cancer(Fe?Al?Zn?Se).Zn and Fe may be the precacerous factor; Cu may be the result after gastric cancer. The values of Cu?Cu/Zn?Fe in serum could offer the foundation for early diagnosis of gastric cancer.