急性脑梗死患者血清sICAM-1含量变化的研究

The levels of serum soluble intercellular adhesion molecule-1 in patient with cerebral ischemia and its clinical significance

目的 :探讨人类脑缺血后血流中可溶性细胞间粘附分子 1(sICAM 1)含量与疾病转归、脑血管病危险因素及病变体积的关系。方法 :采用酶联免疫吸附法 ,测定 35例脑梗死患者血清sICAM 1的含量 ,与 2 0例正常人对照比较。结果 :脑梗死4 8h内和 14d血清sICAM 1含量明显高于正常对照组 (P <0 0 5 ,P <0 0 0 5 )。脑梗死 4 8h内 ,合并高血压、糖尿病患者血清sICAM 1明显高于非高血压、糖尿病患者 (P <0 0 5 ;P<0 0 0 1) ,且血清sICAM 1的含量与血糖水平有明显相关性 (r=0 8857,P <0 0 5 )。动态观察显示 ,脑梗死 4 8h内与 14d血清sICAM 1含量比较无明显变化 ,但血清sICAM 1含量与单发梗死体积有明显相关性 (r=0 4 38,P <0 0 5 ;r=0 5 37,P <0 0 5 )。结论 :ICAM 1与脑梗死的发生发展密切相关 ,其含量受脑血管病危险因素。

Objective:To define the kinetics of soluble intercellular adhesion molecule 1 in serum levels after cerebral ischemia and their correlation with the clinical outcome, infarct volume as measured on CT scans ,and the relevance of vascular risk factors Methods:The levels of serum sICAM 1 were mesured with enzyme linked immunosorbent assay (ELISA) method in 35 patients with acute cerebral infaration and 20 cases of normal control Results:Serum sICAM 1's concentration in the samples of cerebral infarction on second day (P<0 05) and on 14 day (P<0 005) was sigificantly higher than those of the control group In acute cerebral infarction group the concentration of sICAM 1 in the patients with a history of hepertension and diabetes was significantly higher than those without the history of hypertension and diabetes (P<0 05, P<0 001) There was a correlation between the serum sICAM 1's concentrations and the blood sugar levels (r=0 885 7, P<0 05) The sICAM 1 serum levels for patients with cerebral infraction did not significantly decreased after treatment There was a correlation between the levels of sICAM 1 and the sizes of mono focus in CT scans (r=0 43,r,<0 05; r=0 537,P<0 05) Conclusion:The results showed that serum sICAM 1 was closely related to the development of acute cerebral infarction The serum sICAM 1's concentration was influenced by the relevance of the vascular risk factors and the volume of infraction ,and so on