摘要
我们运用光镜、电镜及酶组化,对大鼠皮肤30%Ⅲ度磷烧伤后90天内附睾的病理变化,进行了动态观察。结果发现,附睾上皮细胞、管周组织及腔内精子和退变精细胞,显不同程度的退变与坏死。这些病变的发生和发展大致可分为:损伤起始及反应期;损伤进展期;损伤恢复期。我们认为,在损伤进展期,由于附睾组织的损伤广泛且严重,影响附睾促进精子达到形态、生理和代谢的成熟及附睾的储存功能。随着动物的康复与组织修复,推测磷烧伤对雄性动物远期生育力的影响可能较小。
The present study is to investigate the pathological changes in the epididymis of the rats within a period of 90 days after third degree phosphorus burns involving 30% of TBSA.By light microscopy and electron microscopy and histochemistry,varying degrees of degeneration and necrosis of epididymal epithelial cells,peritubular tissues and luminal spermatozoa and degen- erative spermatid were found.The occurrence and development of all these changes might be divided into:the initiation and reaction phase of injury;the advanced phase;and the recovering phase.It is considered that epididymal tissue damage in advanced phase is so extensive and severe that the morphological,physiological and metabolic maturation of the spermatozoa may be affected,and the storing function of the epididymis as well.With the recovery of the burns,there was repair of the damaged tissues,and it could be inferred that the effect of phosphorus burns on the long-term reproductive capacity of male animals is probably mild.