摘要
阻断大白鼠腹部岛状皮瓣静脉8小时后,于解除阻断的同时,经股静脉注入羟自由基清除剂甘露醇,改善微循环的药物654-2和生理盐水对照比较,表明均有提高瘀血后皮瓣成活率的功效。生化指标检测结果显示,两种药物不影响皮瓣组织细胞内黄嘌呤氧化酶(XOD)的活性,但可降低其脂质过氧化物(LPO)和水的含量。
Rat abdominal skin flaps were subjected to total venous occlusion for 8 hours.Prior to and immediately following release of the vascular occlusion,mannitol,anisodamin or placebos were administered.Mannitol and/or anisodamin significantly enhanced island flap survival.LPO or water content was significantly lower in drug groups than in placebo groups.However, XOD was not affected by the drugs.These findings indicated that oxygen free-radical played an important role in post-ischemic flap injury.
