摘要
我们应用放免法测定了30例烧伤病人(平均年龄36岁,平均烧伤面积38.1%±30.0%)及20例正常人血中β内啡肽样免疫活性物质[ir-β-内啡肽(ir-β-EP)]的含量,结果提示血中ir-β-EP含量与烧伤面积及严重程度呈正相关(r=0.576),并且在手术、创面感染、败血症休克、心衰及脑水肿等并发症出现时升高,死亡前可达3000pg/ml。因而测定血中ir-β-EP含量的变化,有利于临床上判定病情及估计预后。
The plasma immunoreactive β-endorpbin (ir-β-EP) contents in 20 healthy volunteers and 30 burned patients (averaqe age: 36 years, average burn area: 38.15 ± 30.0% of TBSA) were determined by radioimmunoassay (RIA). Results showed that there were significant increases of plasma ir-β-EP in burned patients, which correlated to the extents of the burn areas positively (r = 0.576). Raised ir-β-EP contents wefe also observed in the complications of operation, wound infecfion, septicaetnic shock, heart failure and brain edema, which reached as high as 3000pg/ml before death. The above findings suggested that the determi- nation of plasma β-EP might he helpful in understanding injury extent and evaluating prognosis.
