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用于肿瘤治疗的^(90)Y标记单克隆抗体和受体 被引量：2

^(90)Y-labeled Monoclonal Antibodies and Peotide-receptor for Tumor Radiotherapy
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摘要 简述了90Y标记McAb和肽-受体的标记方法、动物实验、临床应用以及剂量估算等方面的研究概况。 90Y is a useful radionuclide for radiotherapy due to its energetic β- ray(Emax=2.3 MeV)and favorable halflife(T1/2=64 h) and it can be obtained from 90Sr90Y generator for the carrierfree form. The radiolabeling methods, toxicity and dose estimation in animal and clinical application for the cancer treatment with 90Y labeled monoclonal antibodies and peptidereceptor are summarized.
作者 范我
机构地区 苏州大学核医学院
出处 《同位素》 CAS 2002年第3期168-174,共7页 Journal of Isotopes
关键词 标记 单克隆抗体 受体 肿瘤 治疗 钇90 放射性核素 ^(90)Y monoclonal antibodies and peptide-receptor cancer therapy
分类号 R730.55 [医药卫生—肿瘤]
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参考文献5

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同被引文献28

  • 1张锦明,林琼芳,金小海.^(90)Y标记抗体的双功能络合剂的研究——异硫氰基苄基DTPA与环化DTPA酸酐的比较[J].核化学与放射化学,1993,15(4):219-223. 被引量：2
  • 2夏忠军,王风华,黄慧强,骆卉妍,李宇红,林桐榆,姜文奇,管忠震.含美罗华方案治疗B细胞性惰性淋巴瘤34例报告[J].癌症,2006,25(4):490-494. 被引量：9
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  • 4Sandmaier BM, Bethge WA, Wilbur DS, et al. Bismuth 213 -labelled anti - CD45 radioimmunoconjugate to condition dogs for nonmyeloablatlve allogeneic marrow grafts. Blood. 2002, 100:318.
  • 5Matthews DC, Appelbanm FR, Eary JF, et al. Phase Ⅰ study of ^131I - anti - CD45 antibody plus cyclophosphamide and total body irradiation for advanced acute leukemia and mydedysplastic syndrome. Blood. 1999,94 : 1237.
  • 6Wagner HN, Wiseman GA, Marcus CS, et al. Administration guidelines for radioimmunotherapy of non - Hodgkin' s lymphoma with ^90y -labelled anti -CD20 monoclonal antibody. J Nucl Med. 2002, 43:267.
  • 7Stimmel JB, Stockstill ME, Kull FC. ^90Y chelation properties of tetraacetic acid macrocycles, diethyle netriamine pentaacetic acid analogues, and a novel terpyridine acyclic chelator. Bioconjug Chem. 1995, 6:219.
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