摘要
应用GC-MS/SIM定量方法研究了盐酸戊乙奎醚外消旋体在家兔体内的药代动力学。结果表明,家兔单剂量肌注盐酸戊乙奎醚外消旋体后,其血药时程符合一级吸收二室模型。盐酸戊乙奎醚外消旋体在家兔体内的主要药动学参数为:t1/2α=0.12 h, t1/2β=8.40 h, t1/2Ka=0.024 h,Tmax=0.068 h, Cmax =30.21 ngmL-1,AUC =107.55 ngmL-1h。研究结果为盐酸戊乙奎醚在兽医临床上的合理应用提供了科学依据。
The pharmacokinetics of penehyclidine hydrochloride (PH) raceme were investigated in rabbitsby the method of gas chromatography-mass spectrometry/selected ion monitoring (GC-MS/SIM). Theblood drug concentration time curves in rabbits were all best fitted to first order absorption two-compart-ment open model after i.m. a single dose PH (0.1 mgkg-1). The main pharmacokinetic parameters of PHraceme were as follows: t1/2α=0.12 h, t1/2β=8.40 h, t1/2Ka=0.024 h, Tmax =0.068 h, Cmax= 30.21 ngmL-1,AUC=107.55 ngmL-1h. The method was constant, sensitive, and accurate. It provides a useful method forthe determination of pharmacokinetics of penehyclidine hydrochloride which are important for clinical useof penehyclidine hydrochloride.
出处
《中国兽药杂志》
2002年第8期17-19,4,共4页
Chinese Journal of Veterinary Drug
