肌萎缩侧索硬化实验模型及发病机制研究进展
摘要
肌萎缩侧索硬化(ALS)病因及发病机制的研究一直是神经科较棘手的问题。本文介绍最近对ALS研究较多的几种模型:免疫介导的动物模型、体外细胞培养模型及转基因动物模型,并介绍各自的优、缺点,适应研究的方向及由此而阐明的发病机制。为今后研究ALS的发病机制及治疗方案奠定基础。
出处
《国外医学(神经病学.神经外科学分册)》
2002年第4期308-310,共3页
Foreign Medical Sciences(Section On Neurology & Neurosurgery)
参考文献14
-
1Engelhardt JI, Appel SH, Killian JM. Motor neuron destruction in guinea pigs immunized with bovine spinal cord ventral horn homogenate: experimental autoimmune gray matter disease. J Neuroimmunol, 1990, 27(1): 21-31.
-
2Colom LV, Alexianu ME, Mesier DR, et al. Amyotrophic lateral sclerosis immunoglobulins increase intracellular calcium in a motoneuron cell line. Exp Neurol, 1997, 146(2): 354-360.
-
3Azzouz M, Poindron P, Guettier S. Prevention of mutant SODI motoneuron degeneration by copper chelators in vitro. J Neurobiol, 2000, 42(1) : 49-55.
-
4Bataille S, Potalier P, Coulon P, at al. Influence of acetyleholinesterase on embryonic spinal rat motoneurons growth in culture: a quantitative morphometric study. Eur J Neurosci, 1998, 10(2) : 560-572.
-
5Bar PR. Motor neuron disease in vitro: the use of cultured motor neurons to study amyotrophic lateral sclerosis. Eur J Pharmacol, 2000, 405(1-3): 285-295.
-
6Kaal EC, Vlug AS, Versleijen MV, et al. Chronic mitocnondrial inhibition induces selective motoneuron death in vitro: a new model for amyotraphic lateral sclerosis. J Neurochem, 2000, 74(3): 1158-1165.
-
7Drachman DB, Rothstein JD. Inhibition of cyclooxygenase - 2 protects motor neurons in an organotypic model of amyotrophic lateral sclerosis. Ann Neurol, 2000, 48(5): 792-795.
-
8Silani V, Braga M, Ciammola A, et al. Motor neurones in culture as a model to study ALS. J Neurol, 2000, 247 (Suppl 1 ) : 128-136.
-
9Gonzalez de Aguilar JL, Gordon JW, Rene F, et al. Alteration of the Bcl- x/Bax ratio in a transgenic mouse model of amyotraphic lateral sclerosis: evidence for the implication of the p53 signaling pathway. Neurobiol Dis, 2000, 7(4): 406- 415.
-
10Andreassen OA, Dedeoglu A, Klivenyi P, et al. N - acetyl - L- cysteine improves survival and praserves motor performance in an animal model of familial amyotrophic lateral sclerosis. Neuroreport, 2000, 11 (11): 2491- 2493.
-
1陈娜,刘叶红,刘小静,陈云茹,郭永红,刘敏.氧化苦参碱抑制体外细胞培养模型HCV感染靶细胞研究[J].中华肝脏病杂志,2016,24(1):40-45. 被引量:4
-
2龚敏,李树清,李凡.树鼩脑星形胶质细胞的体外培养及纯化[J].生理学报,2011,63(1):89-92. 被引量:2
-
3陈娜,刘叶红,刘敏.HCV细胞培养系统研究进展[J].传染病信息,2012,25(5):317-320.
-
4王菁华,张建华,于瑞洪,穆莉莉,刘玉梅,刘传亮,王广友.t-PA对EAE病理性淋巴细胞与血脑屏障粘附的影响[J].现代生物医学进展,2015,15(27):5208-5211.
-
5王姝,金敏,郭向飞,王新为,邱志刚,谌志强,李君文.人胎肝干细胞体外感染乙型肝炎病毒模型的建立[J].解放军预防医学杂志,2011,29(3):168-172. 被引量:1
-
6马爱民,陈华利,颜军.大学新生应对效能在心理应激与适应间中介作用的追踪调查[J].中国学校卫生,2017,38(3):393-395. 被引量:7
-
7吴光华,张云,郭恒彬.小盾纤恙螨经卵传递病原体研究[J].中国媒介生物学及控制杂志,2004,15(4):301-303. 被引量:11
-
8史秀山,王勇,黎明哲.狂犬病固定毒aG株在Vero细胞上的传代适应研究[J].中国热带医学,2004,4(6):933-934. 被引量:4
-
9宋晓东,刘玉清,王汉卿,李佳,张禅那,惠汝太.黄芪总提取物对心肌细胞的保护作用及对c-myc基因表达的影响[J].中国分子心脏病学杂志,2003,3(1):3-6. 被引量:5
-
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