原发性和继发性GBM分子遗传水平研究进展
被引量：1
摘要
胶质母细胞瘤Glioblastoma（GBM）可以分为原发性和继发性两种。这两种肿瘤的病理组织学改变在光学显微镜下很难区分,但在发生、发展、临床表现及预后均有显著差异。原发性GBM特征性分子遗传学改变是EGFR基因的扩增、10号染色体杂合性的缺失,多数伴有PTEN的突变、P16INK4a杂合性的缺失及MDM2的扩增。继发性GBM特征性的分子遗传学改变为P53基因突变和染色体17p杂合性的缺失,大多数也存在10q、19q杂合性丢失。
出处
《国外医学（神经病学．神经外科学分册）》
2002年第4期366-369,共4页
Foreign Medical Sciences（Section On Neurology & Neurosurgery）
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